{
  "timeline": [
    {
      "date": "1911/11",
      "category": "会社設立",
      "region": "",
      "importance": 3,
      "event": "京都新薬堂を創設",
      "detail": "1911年11月、市野瀬潜が京都に新薬の輸入販売を行う個人商店「京都新薬堂」を創業した。",
      "significance": "日本新薬の創業起点。輸入医薬品の卸販売から始まった事業基盤",
      "source": "有価証券報告書"
    },
    {
      "date": "1919/10",
      "category": "会社設立|組織再編",
      "region": "",
      "importance": 3,
      "event": "株式会社化し日本新薬株式会社へ商号変更",
      "detail": "1919年10月、市野瀬潜と内貴清兵衛らが京都新薬堂を法人化し、日本新薬株式会社として設立。",
      "significance": "個人商店から株式会社化、現在の法人格を確立した",
      "source": "有価証券報告書"
    },
    {
      "date": "1920/6",
      "category": "設備投資",
      "region": "",
      "importance": 1,
      "event": "本社・工場を京都市下京区壬生下溝町へ移転",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1928/7",
      "category": "",
      "region": "",
      "importance": 1,
      "event": "東京出張所（現東京支店）設置",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1929/8",
      "category": "研究開発",
      "region": "",
      "importance": 2,
      "event": "みぶよもぎ花蕾から国産サントニン結晶を抽出",
      "detail": "1926年4月から探索した回虫駆除薬サントニン含有の新植物「みぶよもぎ」から2.4gの結晶を抽出。",
      "significance": "輸入依存からの脱却と国産創薬技術の基礎",
      "source": "有価証券報告書"
    },
    {
      "date": "1934/5",
      "category": "設備投資",
      "region": "",
      "importance": 1,
      "event": "京都市西大路八条に西大路工場を設置",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1935/2",
      "category": "研究開発",
      "region": "",
      "importance": 1,
      "event": "薬用植物研究のため山科研究圃場（現山科植物資料館）を設置",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1940/5",
      "category": "新規事業",
      "region": "",
      "importance": 3,
      "event": "国産サントニンの発売",
      "detail": "輸入依存から脱却した自社製造の回虫駆除薬として量産販売を開始。",
      "significance": "輸入依存から自社製品メーカーへ転換した分水嶺",
      "source": "有価証券報告書"
    },
    {
      "date": "1940/9",
      "category": "",
      "region": "",
      "importance": 1,
      "event": "大阪支店（現関西支店）設置",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1944/10",
      "category": "設備投資",
      "region": "",
      "importance": 1,
      "event": "サントニン現地生産のため札幌工場を設置",
      "detail": "1990年9月に閉鎖。",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1949/6",
      "category": "株式上場",
      "region": "",
      "importance": 3,
      "event": "京都証券取引所に株式上場",
      "detail": "",
      "significance": "株式市場での資金調達基盤を確立した戦後復興期の上場",
      "source": "有価証券報告書"
    },
    {
      "date": "1954/3",
      "category": "設備投資",
      "region": "",
      "importance": 1,
      "event": "西大路工場内に総合工場を設置",
      "detail": "2001年11月に京都工場を閉鎖。",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1956/3",
      "category": "株式上場",
      "region": "",
      "importance": 2,
      "event": "大阪証券取引所に株式上場",
      "detail": "",
      "significance": "京都に加え関西の主要証券取引所での上場",
      "source": "有価証券報告書"
    },
    {
      "date": "1957/2",
      "category": "",
      "region": "",
      "importance": 1,
      "event": "本社及び壬生工場を西大路工場敷地内に移転",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1960/8",
      "category": "業務提携",
      "region": "",
      "importance": 2,
      "event": "黒石製薬株式会社（現連結子会社シオエ製薬）と提携",
      "detail": "",
      "significance": "医薬品事業の補完関係を構築",
      "source": "有価証券報告書"
    },
    {
      "date": "1961/5",
      "category": "新規事業",
      "region": "",
      "importance": 3,
      "event": "食品事業に参入。スパイス工場を建設し粉末香辛料「スパイス・ケンダ」発売",
      "detail": "医薬品事業に加え機能食品（スパイス）への進出。",
      "significance": "医薬品単一事業から多角化に踏み出した転換点",
      "source": "有価証券報告書"
    },
    {
      "date": "1962/4",
      "category": "研究開発",
      "region": "",
      "importance": 2,
      "event": "新研究所（現創薬研究所3号館）設置",
      "detail": "",
      "significance": "医薬品研究体制の本格整備",
      "source": "有価証券報告書"
    },
    {
      "date": "1962/9",
      "category": "株式上場",
      "region": "",
      "importance": 3,
      "event": "東京証券取引所に株式上場",
      "detail": "京都・大阪に続く三市場上場により全国市場での資金調達基盤を確立。",
      "significance": "東京市場進出による全国的な資本市場アクセスの完成",
      "source": "有価証券報告書"
    },
    {
      "date": "1964/7",
      "category": "設備投資",
      "region": "",
      "importance": 2,
      "event": "東日本の医薬品生産拠点として小田原工場を設置",
      "detail": "",
      "significance": "東日本での生産拠点を確立、首都圏供給力強化",
      "source": "有価証券報告書"
    },
    {
      "date": "1966/12",
      "category": "設備投資",
      "region": "",
      "importance": 1,
      "event": "食品専門工場として盛岡工場を設置",
      "detail": "2008年8月に閉鎖。",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1970/10",
      "category": "研究開発",
      "region": "",
      "importance": 1,
      "event": "食品技術研究所（現食品開発研究所）設置",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1970/12",
      "category": "企業買収",
      "region": "",
      "importance": 1,
      "event": "タジマ食品工業株式会社（連結子会社）へ資本参加",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1982/3",
      "category": "研究開発|設備投資",
      "region": "",
      "importance": 2,
      "event": "中央研究所本館（現創薬研究所1号館）設置",
      "detail": "",
      "significance": "創薬研究体制の中核施設を整備",
      "source": "有価証券報告書"
    },
    {
      "date": "1990/10",
      "category": "設備投資",
      "region": "",
      "importance": 1,
      "event": "千歳クリエートパーク設置",
      "detail": "2013年4月に浜理薬品工業へ譲渡。",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1991/3",
      "category": "",
      "region": "",
      "importance": 1,
      "event": "東京支社設置",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1991/4",
      "category": "海外進出",
      "region": "欧州",
      "importance": 1,
      "event": "デュッセルドルフ事務所開設",
      "detail": "2012年4月にロンドンへ移転。",
      "significance": "欧州市場の情報収集拠点",
      "source": "有価証券報告書"
    },
    {
      "date": "1994/4",
      "category": "設備投資",
      "region": "",
      "importance": 1,
      "event": "西部創薬研究所2号館（現創薬研究所2号館）設置",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "1997/6",
      "category": "設備投資|研究開発",
      "region": "",
      "importance": 2,
      "event": "つくば市に東部創薬研究所を設置",
      "detail": "",
      "significance": "首都圏研究拠点として基礎研究を強化",
      "source": "有価証券報告書"
    },
    {
      "date": "1997/10",
      "category": "海外進出",
      "region": "米州",
      "importance": 2,
      "event": "ニューヨーク事務所開設",
      "detail": "1999年7月にNS Pharma",
      "significance": "",
      "source": "米国市場進出の橋頭堡",
      "amount": " Inc.として現地法人化。"
    },
    {
      "date": "2001/2",
      "category": "組織再編|設備投資",
      "region": "",
      "importance": 2,
      "event": "医薬品製剤の生産機能を小田原工場に集約化し小田原総合製剤工場と改称",
      "detail": "",
      "significance": "生産拠点の集約と効率化",
      "source": "有価証券報告書"
    },
    {
      "date": "2002/5",
      "category": "海外進出",
      "region": "米州",
      "importance": 1,
      "event": "NS Pharma",
      "detail": " Inc.をニュージャージー州へ移転",
      "significance": "",
      "source": ""
    },
    {
      "date": "2006/4",
      "category": "組織再編",
      "region": "",
      "importance": 1,
      "event": "ラプラスファルマ株式会社（連結子会社）を設立",
      "detail": "2009年10月解散。",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "2011/12",
      "category": "海外進出",
      "region": "中国",
      "importance": 1,
      "event": "北京事務所開設",
      "detail": "2023年1月閉鎖。",
      "significance": "中国市場の情報収集拠点",
      "source": "有価証券報告書"
    },
    {
      "date": "2016/3",
      "category": "設備投資|研究開発",
      "region": "",
      "importance": 2,
      "event": "本社敷地内に治験原薬製造棟を設置",
      "detail": "",
      "significance": "核酸医薬を含む新規モダリティ製造体制",
      "source": "有価証券報告書"
    },
    {
      "date": "2017/7",
      "category": "設備投資",
      "region": "",
      "importance": 1,
      "event": "小田原総合製剤工場敷地内に高生理活性固形製剤棟設置",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "2021/9",
      "category": "海外進出",
      "region": "中国",
      "importance": 2,
      "event": "中国現地法人 北京艾努愛世医薬科技有限公司（連結子会社）設立",
      "detail": "",
      "significance": "中国市場本格進出",
      "source": "有価証券報告書"
    },
    {
      "date": "2021/11",
      "category": "海外進出",
      "region": "中国",
      "importance": 2,
      "event": "中国現地法人 天津艾努愛世医薬有限公司（連結子会社）設立",
      "detail": "",
      "significance": "中国生産・販売体制の構築",
      "source": "有価証券報告書"
    },
    {
      "date": "2022/4",
      "category": "",
      "region": "",
      "importance": 1,
      "event": "東京証券取引所プライム市場へ移行",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "2023/1",
      "category": "組織再編",
      "region": "中国",
      "importance": 1,
      "event": "北京事務所の事業を中国子会社へ移管",
      "detail": "",
      "significance": "",
      "source": "有価証券報告書"
    },
    {
      "date": "2023/1",
      "category": "海外進出",
      "region": "米州",
      "importance": 1,
      "event": "NS Pharma",
      "detail": " Inc.がマサチューセッツ州ケンブリッジに新オフィス開設",
      "significance": "",
      "source": "米国研究開発拠点の拡張"
    }
  ]
}