{ "spec_version": "3", "endpoint": "history", "stock_code": "4516", "company_name": "日本新薬", "content_lang": "ja", "meta_lang": "en", "canonical_url": "https://the-shashi.com/tse/4516/decisions/", "api_url": "/api/4516/history.json", "updated": "2026-09-08", "license": "© 2026 Yutaka Sugiura. All rights reserved.", "attribution": "The社史 (the-shashi.com) — https://the-shashi.com/tse/4516/decisions/", "source": { "chapters": { "html_url": "https://the-shashi.com/tse/4516/", "primary": [ "社史", "有価証券報告書", "新聞・雑誌記事" ], "extraction": "一次資料を読み合わせて執筆" }, "long_term": { "primary": [ "会社年鑑", "会社年鑑（1976年版）" ], "extraction": "EDINET の XBRL、kabupro 掲載の旧有価証券報告書、会社年鑑・社史等からの転記", "row_field": "reference", "caveat": "創業期から現在までを 1 本に繋いだ長期系列のため、年代により出所・単位・連結範囲が変わる。行ごとの reference / unit / consolidation を必ず参照すること" }, "decisions": { "html_url": "https://the-shashi.com/tse/4516/decisions/", "primary": [ "企業の公表資料", "新聞・雑誌記事" ], "extraction": "本文は API に載せない。行ごとの html_url のページを参照すること" } }, "title": "日本新薬の歴史概略", "summary": { "title": "サマリー", "text": "", "description": "日本新薬（旧京都新薬堂）の歴史。1911年、市野瀬潜氏が京都で創業。国産サントニンの製造と食品事業への参入を経て、難病・希少疾患への絞り込みと核酸医薬ビルテプソの米国承認までの沿革と経緯を執筆。" }, "eras": [ { "title": "京都新薬堂からサントニン国産化まで", "start_year": 1911, "end_year": 1948 }, { "title": "京都・大阪・東京の三市場上場と多角化", "start_year": 1949, "end_year": 2001 }, { "title": "核酸医薬と希少疾患領域への集中", "start_year": 2002, "end_year": 2026 } ], "overview": [ { "label": "創業", "text": "1911年11月、市野瀬潜が京都で個人商店\"京都新薬堂\"を創業し、欧米から輸入される医薬品の卸売を始めた。扱った薬の筆頭は高価な輸入品の回虫駆除薬サントニンで、その国産化を見据えて1919年10月、内貴清兵衛らと資本金50万円の株式会社へ改組し、社名を日本新薬へ改めた。京都市下京区壬生下溝町に本社と工場を構え、翌1920年5月から皮膚薬ピチロールと催眠薬ブロバリンの製造を始めている。原料植物の種苗はロシアが国外持ち出しを禁じており、1926年に始めた探索が国産サントニンの発売に至るのは、みぶよもぎの命名を経た1940年5月だった。" }, { "label": "決断", "text": "日本だけを手元に残す売り方を、2020年にやめた。1926年から15年かけてサントニンを国産化した会社だが、創った薬を海外で自ら売る組織は長く持たなかった。2008年2月に[セレキシパグの日本を除く全世界の開発販売権をアクテリオンへ導出し](/tse/4516/decisions/selexipag-licensing-2008/)、マイルストーンとロイヤルティで開発費を回収する形を選んでいる。国内中堅の販売網では欧米の専門医へ自力で届かないという判断だった。2020年8月、[核酸医薬ビルテプソの米国承認を取得して自社販売を始め](/tse/4516/decisions/viltepso-us-direct-sales-2020/)、1999年に現地法人化したNS Pharmaを販売会社へ作り替えた。患者数が限られる希少疾患ほど届け先が専門の医療機関と患者団体に集まるため、少人数の営業でも自ら届けられる。この読みが、導出しか選べなかった条件を変えた。" }, { "label": "現況", "text": "1961年に始めた食品事業は、売上の13%を占めて利益をほとんど生まない。2026年3月期の売上高1,707億円のうち医薬品が1,484億円・セグメント利益333億円、機能食品は222億円・8億円である。全社の営業利益は354億円、当期純利益297億円だった。2019年5月の[第六次中期経営計画で注力領域を絞り込んで](/tse/4516/decisions/rare-disease-focus-2019/)以降、自社創薬の対象は難病・希少疾患と泌尿器・血液内科に限られ、2021年に設けた中国子会社と米NS Pharmaが海外の窓口となっている。人員も医薬品1,852名に対し機能食品は174名にとどまり、配分の偏りがそのまま利益の偏りを生んでいる。" }, { "label": "競合", "text": "海外の営業組織を、買収ではなく駐在事務所から育てた。[塩野義製薬が米サイエル・ファーマをTOBで完全子会社化した](/tse/4507/decisions/sciele-acquisition-2008/)のは2008年で、約14億ドルを投じて生活習慣病の医師を回る営業組織を得ながら、4年後にはHIV治療薬を自ら売る道を閉じている。日本新薬は1991年のデュッセルドルフ事務所、1997年のニューヨーク事務所を経て1999年にNS Pharmaを置き、20年かけて販売会社へ変えた。売上1,707億円は塩野義製薬の3分の1にとどまるが、デュシェンヌ型筋ジストロフィーを診る施設は米国でも限られ、少人数で回れる。患者数の少なさが、中堅の営業規模でも自社販売を成り立たせている。" } ], "profile": [ { "key": "founding_business", "label": "祖業", "value": "欧米から輸入した医薬品の卸売" }, { "key": "current_issue", "label": "現在の注力課題", "value": "難病・希少疾患と泌尿器・血液内科への集中", "tags": [ "研究開発", "海外展開" ] } ], "auditVersion": 3, "foundingStory": true, "chapters": [ { "start_year": 1911, "end_year": 1948, "main_title": "京都新薬堂からサントニン国産化まで", "subsections": [ { "title": "輸入販売の個人商店から法人化への踏み出し", "text": "1911年11月、市野瀬潜が京都で個人商店\"京都新薬堂\"を創業した。明治末期から大正初期にかけて、欧米から輸入される医薬品の卸販売を主な事業として始まり、京都という古都ながら学術都市の立地が、後年の研究開発志向につながった。この個人企業を前身に、1919年10月、市野瀬潜と内貴清兵衛らが資本金50万円の株式会社として改組設立し、社名を日本新薬株式会社へ改めた。輸入商社から国産製薬会社へ生まれ変わるための法人格を整え、京都市下京区壬生下溝町に本社・工場を構えた。翌1920年5月には壬生の本社事務所と工場で皮膚薬ピチロール、催眠薬ブロバリンなどの製造を始め、輸入医薬品を卸す商店から自社で薬を製造する医薬品メーカーへ転じた。\n\n1926年4月から、回虫駆除薬サントニン含有の新植物の探索が始まった。1929年8月、自社は新植物の花蕾から国産サントニン結晶2.4gを抽出することに成功し、その新植物を\"みぶよもぎ\"と命名した。1934年5月、京都市西大路八条に西大路工場を設置し、1935年2月には薬用植物研究のため山科研究圃場（現山科植物資料館）を整備した。輸入依存の事業構造から、自社研究で国産化を目指す方向へ方針を変える時期で、薬用植物の栽培から成分抽出までを日本新薬で担う体制を構築している。", "references": [ { "title": "日本新薬 有価証券報告書【沿革】", "year": null, "month": null, "date": null, "url": null, "quotes": [] }, { "title": "企業の歴史 : 明治百年（経済春秋社編, 1968）", "year": null, "month": null, "date": null, "url": null, "quotes": [] } ] }, { "title": "国産サントニン発売と戦時期の生産拡張", "text": "1940年5月、1926年の探索開始から実に15年に及ぶ研究の末に、国産サントニンを発売した。輸入依存から脱却した自社製造の回虫駆除薬として量産販売を開始し、日本新薬の事業基盤を確立する画期となった。同年9月に大阪支店（現関西支店）を設置し、1944年10月にはサントニン現地生産のため札幌工場を設置している。戦時期の医薬品需要拡大と国産化政策のなかで、京都本社・大阪支店・札幌工場の三拠点体制を整え、医療用医薬品メーカーとしての地位を得た。\n\n戦時期の生産拡張は、戦後の事業基盤の礎となった。1948年に商店の医薬品製造部門と医薬硝子資材部門を分離して株式会社化する小野薬品工業と異なり、日本新薬は早期に株式会社化を済ませた優位性を活かし、戦後の混乱期にも事業の連続性を保った。1944年10月設置の札幌工場は後の1990年9月に閉鎖されるが、戦時期に整えた複数拠点の生産体制が、戦後の医薬品需要拡大に応える基盤となった。", "references": [ { "title": "日本新薬 有価証券報告書【沿革】", "year": null, "month": null, "date": null, "url": null, "quotes": [] }, { "title": "企業の歴史 : 明治百年（経済春秋社編, 1968）", "year": null, "month": null, "date": null, "url": null, "quotes": [] } ] } ] } ], "long_term": [ { "year": 1949, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1950, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1951, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1952, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1953, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1954, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1955, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1956, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1957, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1958, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1959, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1960, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1961, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1962, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1963, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1964, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1965, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1966, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1967, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1968, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1969, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1970, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": null, "sales": null, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": null, "ordinary_profit": null, "net_profit_jp": null, "net_profit": null, "net_margin": null, "employees": null, "reference": null }, { "year": 1971, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": "売上高", "sales": 110, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": "経常利益", "ordinary_profit": 20, "net_profit_jp": "当期純利益", "net_profit": 10, "net_margin": 9.09, "employees": null, "reference": "会社年鑑（1976年版）" }, { "year": 1972, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": "売上高", "sales": 117, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": "経常利益", "ordinary_profit": 16, "net_profit_jp": "当期純利益", "net_profit": 8, "net_margin": 6.837, "employees": null, "reference": "会社年鑑（1976年版）" }, { "year": 1973, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": "売上高", "sales": 129, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": "経常利益", "ordinary_profit": 15, "net_profit_jp": "当期純利益", "net_profit": 7, "net_margin": 5.426, "employees": null, "reference": "会社年鑑（1976年版）" }, { "year": 1974, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": "売上高", "sales": 158, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": "経常利益", "ordinary_profit": 19, "net_profit_jp": "当期純利益", "net_profit": 7, "net_margin": 4.43, "employees": null, "reference": "会社年鑑（1976年版）" }, { "year": 1975, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": "売上高", "sales": 202, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": "経常利益", "ordinary_profit": 27, "net_profit_jp": "当期純利益", "net_profit": 7, "net_margin": 3.465, "employees": null, "reference": "会社年鑑（1976年版）" }, { "year": 1976, "month": 3, "company_name": "日本新薬", "consolidation": "単体", "accounting_standard": "JGAAP", "unit": "億円", "sales_jp": "売上高", "sales": 221, "operating_profit_jp": null, "operating_profit": null, "ordinary_profit_jp": "経常利益", "ordinary_profit": 25, "net_profit_jp": "当期純利益", "net_profit": 9, "net_margin": 4.072, "employees": null, "reference": "会社年鑑" }, { "year": 1977, "month": 3, 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"https://the-shashi.com/tse/4516/decisions/rare-disease-focus-2019/" }, { "title": "国産初のアンチセンス核酸医薬ビルテプソの承認取得と、米国での自社販売開始", "year": 2020, "type": "overseas", "html_url": "https://the-shashi.com/tse/4516/decisions/viltepso-us-direct-sales-2020/" } ] }